126 BIBLIOGRAPHY OF 



EMERY, W. O., 1891. 



Ber. 24, 282-286 ; J. Chem. Soc. 60, 547. 

 Action of /9=Bromopropionic Ester on Acetoacetic Ester. 



By the action of /9-bromopropionic ester on sodacetoacetic ester, 



CH, 



CO 

 a-acetylglutaric ester, CH — CH2 — CH2 CO2 C2 H5 , was produced. It 



CO2 C2 Hj 

 boils at 162° at 11 m. m. pressure and has a specific gravity of 1.07 1 at 

 20." It reacts with ammonia and with aniins, yielding amido-derivatives 

 of a-ethylidineglutaric ester, which can be converted into lactams. 



HANTZSCH, A., 1891. 



Ber. 24, 495-506 ; J. Chem. Soc. 60, 739. 

 Action of Hydroxylamin on /9=Ketonic Acids and /5-Diketones. 



By the action of hydroxylamin on acetoacetic ester in alkaline solu- 

 tion and subsequent acidification the chief product is methyl-isoxazol- 



^N — O 

 one, CH,C I , which melts at 169°-! 70'' and is a base towards 



•^CH2 CO 



strong acids. In alkaline solutions it is partially changed into oximido- 

 butyric acid, CH3 C : (NOH) CH2 CO^ H . By the action of hydroxyl- 

 amin on acetoacetic ester in neutral or acid solution, an oil is obtained 

 which, on being hydrolyzed, gives a crystalline substance, C20 H26 N4 

 O7 , which melts at 140° and can by hydrolysis be changed into methyl- 

 isoxazolone. By the action of hydroxylamin on acetoacetic ester in 

 ammoniacal solution an unstable product was obtained which may be 



/ OFT 

 the hydroxamic acid of acetoacetic acid, CH3 CO CH^ C >. ^/-.tt. 



