2248 Journal of Applied Microscopy 



„ .', u ,, , ,. ^ . ,, , , The author opens in the work here 



Habak, n. Ueber die Lntwicklungder locomo- 

 torischen Coordinations-thati.gkeit in Riick- reported a new and promising held in 

 enmarke des Frosches. Arch. f. d. ges. ^-^g 3^^^ ^f t^e ontogenetic develop- 

 Physiol. 93: 134-162,1902. •' . 



ments of, and ontogenetic changes in 



the physiological functions of the different parts of the body. He points out the 



fact that there has been no thorough systematic investigation of the ontogenetic 



development of the functions of the nervous system. The present work deals 



with the development of the function of the locomotor coordination in the spinal 



cord of the frog. Experiments were performed on the larvae of different ages 



and on very young and partially metamorphosed frogs. It was found that in 



young larvas and frogs distal (posterior) parts of the spinal cord have very much 



greater coordinating powers than is the case in the adult, fully grown frog. As 



development proceeds the locomotor coordinating powers become confined to 



more and more proximal parts of the nervous system. A parallel relation of 



course obtains in the phylogenetic series. R. p. 



Abel, J. J. On the Elementary Composition of Attempts to purify and obtain constant 

 Adrenalin. Proc. Amer. Physiol. Soc. Fif- 1, • .1 t ■ r ^^ 



teenth Ann. Meeting. Amer. Jour. Physiol. results in the analysis of the very in- 



8: xxix-x.xx, 1903 teresting substance adrenalin have not 



Amberg, S. The Toxicity of Epinephrin so far been successful. Abel found in 

 (Adrenalin). Ibid. Pp. xxxiii-xxxiv, 1903. . , , ^1 r n • 



^ a series of analyses the following ex- 



tremes of variation in the content of C, H and N. C ^ 56.53 to 58.89; H = 

 4.77 to 7.19 ; N = 7.59 to 10.65 (Dumas). It was found that frequent repreci- 

 pitations of adrenal if dissolved in dilute HCl by means of ammonia or sodium 

 carbonate raised the carbon content of the compound. In the earlier part of 

 the work the analyses gave results which made it possible to deduce for adre- 

 nalin the formula, C^qH^.^NO^, ^HgO, but it was found that the method used 

 in the determination of the nitrogen (Kjeldahl-Gunning) did not give the whole 

 of this element, so that this formula will not hold. 



Amberg found that 2.0 mgm. per kg. of adrenalin injected intravenously in- 

 to a dog caused death. 6.0 mgm. per kg. injected subcutaneously was 

 fatal. The pathological changes produced by the drug consist in hemorrhages, 

 which were observed in the heart, lungs, intestines, peritoneum, in and around 

 the pancreas, liver, adrenal gland and thymus glands. r. p. 



„ . n n J X n iij x^ r. About 3. ycar ago Loeb and Lewis 



uorham, F. P. and Tower, R. W. Does Potas- -' ° 



sium Cyanide prolong the Life of the Un- (Amer. Jour. Physiol. 6: 305) an- 



fertilized Egg of the Sea-Urchin ? Amer. ^ounced the discovery that if unfer- 

 Jour. Physiol. 8: 175-182, 1902. •' 



tilized eggs of the sea-urchin were kept 

 for a time in a weak solution of potassium cyanide they retained the power of 

 being fertilized and developing (i. e., lived) considerably longer than eggs left in 

 ordinary sea water. From this they concluded that KCN " prolonged " the life 

 of the egg, by " checking specilic mortal processes."' 



Gorham and Tower find as the result of an extensive series of careful experi- 

 ments on the eggs of the winter flounder, Pseudopleuronectes americana and of the 

 •sea-urchin Arhacia pitiictiilata, that the action of potassium cyanide in "prolong- 

 ing " the life of the egg is only an indirect one. The poison kills or inhibits the 



