Dec. 15, i02c 



Daubentonia longifolia 



5ii 



actual time for toxic effects to appear was probably rather less than the 

 figures which have been tabulated. 



The time elapsing between a single feeding and the appearance of 

 symptoms is shown in Table II. 



Table II. — Time elapsing between single feeding and appearance of symptoms 



Sheep No. 



Dry weight of 



plant eaten per 



100 pounds of 



animal. 



525 

 528 



548 



533 



55° 



Pounds. 

 O.882 

 .440 

 .066 



Time before 

 symptoms 

 appeared. 



Result. 



Hours. 



8V5 

 29V2 

 26V, 



20V4 



Death. 



Do. 

 Recovery. 

 Death. 



Do. 



It is seen that the time varies from 8'/ 5 hours to 29V2 hours, with an 



average of slightly more than 21 hours. Excluding sheep 528, the 



average would be nearly 24V2 hours. From the experimental work it 



appears that in most cases the symptoms appear in approximately 24 



hours. 



AUTOPSY FINDINGS 



There was a fairly good general agreement in the pictures presented 

 in the autopsies of the five sheep that died. The heart was generally in 

 diastole and the lungs were congested. The fourth stomach in all cases 

 showed more or less congestion. This was true also of the duodenum, 

 jejunum, ileum, and cecum. Congestion in the colon was noted in only 

 one case. The spleen and kidneys were congested, and this condition 

 was found in the pancreas in two cases. The brain and spinal cord 

 showed an unusual fullness of the blood vessels. 



PATHOLOGICAL CHANGES IN TISSUES 



In the animals poisoned, degenerative tissue changes occur principally 

 in lymphoid tissues, smooth muscle, and in the red blood corpuscles. 

 The more delicate cells of the lymph nodules are almost universally found 

 to have undergone degeneration. Tissues composed of smooth muscle 

 fibers are similarly though perhaps not so conspicuously affected. In 

 the blood stream are many thrombi containing degenerated erythrocytes, 

 granular material, and often fibrin. 



Probably the degenerative changes in the erythrocytes and lymphoid 

 tissues are the most important causes of the thrombus formation. Small 

 hemorrhages due to ruptured vessels are not uncommon. Weakening 

 of the muscle layers of the vessels, together with thrombi in the vessels, 

 would appear to be a sufficient cause for the rupture of the vessel walls. 



Degenerative changes also may occur in various glands, as the kidney 

 and liver, but they are less severe than those in the tissues described. 



