Feb. i8, 1918 Efficacy of Some Anthelmintics 405 



The chloroform had an evident anthelmintic effect on the sheep which 

 received the larger dose. The fatal results of the treatment in both 

 cases, however, indicate that chloroform is not a promising anthelmintic 

 for use on sheep. 



ETHKR 



For worms in dogs. — Four dogs weighing from 2.38 to 4.89 kgm. 

 were given ether in a dose of 0.8 mil per kilo mixed with 15 mils of 

 castor oil for the two smaller dogs and 30 mils of castor oil for the two 

 larger dogs. The afternoon of the day before treatment the dogs were 

 given a preliminary dose of castor oil, and were not fed until several hours 

 after receiving the ether. No worms were recovered from the feces passed 

 between the administration of the preliminary dose of castor oil and the 

 administration of the ether and oil mixture. This mixture was much 

 resented by the dogs, and all of them were salivated by it and showed 

 more or less evidence of collapse. One of the dogs passed a few tape- 

 worm segments (Taenia pisiformis), but no other tapeworm material was 

 recovered from the feces ; nor were any tapeworms found post-mortem. 

 No hookworms were recovered from the feces, but all showed infesta- 

 tion on post-mortem examination, the number of worms being 7, 21, 

 233, and 242, respectively. One of the dogs passed i ascarid and one 

 passed 6. At the post-mortem examination no ascarids were found in 

 the former and 11 in the latter. The other two passed no ascarids; 

 4 were found post-mortem in one, but i of these was in the rectum, 

 evidently about to be passed; i ascarid was found post-mortem in the 

 other of these two dogs. 



The conclusion from this experiment is that the ether exhibited a 

 rather slight anthelmintic action against ascarids, no evident action 

 against hookworms, and probably was instrumental in the removal of a 

 tapeworm which was presumably present in one of the dogs, in view of 

 the discovery of segments in the feces. 



iodoform 



For worms in dogs. — Among the remedies prescribed for ascarids in 

 human subjects iodoform has been occasionally recommended. Schid- 

 lowski {quoted by Seifert, 1885, p. g8) gives it in the form of a powder 

 mixed with sodium bicarbonate in doses of o.oi to 0.06 gm. three times a 

 day, followed by a dose of castor oil on the last day. In the present ex- 

 periment it was intended to give the maximum amount, 0.18 gm., in one 

 dose to each of four dogs ranging in weight from 11. 8 to 14 kgm. How- 

 ever, through an error in weighing the drug, the dogs were each given 

 0.018 gm. instead of 0.18 gm. This error was discovered afterward, and 

 the next day the full dose, 0.18 gm., was given. Thus, each dog received 

 a total of about 0.2 gm. of iodoform, given in capsule with sodium bicar- 

 bonate. The dogs were starved for 24 hours before treatment , and allowed 

 one meal between the first and second doses. After each dose 29.6 mils 

 of castor oil were administered. One Taenia segment was passed by one 



