4o6 Journal of Agricultural Research voi.xii, N0.7 



of the dogs, no worms being recovered. As the treatment was obviously- 

 inefficacious, only two of the dogs were killed. The post-mortem exami- 

 nation showed these animals infested with various numbers of intestinal 

 nematodes and tapeworms. As far as can be judged from a single experi- 

 ment, iodoform is valueless as an anthelmintic for intestinal parasites 

 in dogs, even when given in doses in excess of that prescribed for human 

 subjects. 



COPPER SUI.PHATE 



For worms in sheep. — The use of copper sulphate as an anthelmintic 

 against stomach worms in lambs was developed by Hutcheon {1892, 1895), 

 who reported thousands of cases of its successful use in South Africa. 

 His favorable reports were based largely on clinical findings, but in a 

 number of cases he treated animals with the copper-sulphate solution 

 and killed them a short time afterward to determine whether the worms 

 in the stomach were dead or alive. The solution he used is approxi- 

 mately that which would be obtained from 0.45 kgm. of pure copper 

 sulphate, powdered fine and dissolved in 35.96 liters of warm water. 

 Only clear blue crystals are used, and it is best to powder these and 

 then to dissolve the powder in a small quantity of hot water and to add 

 cold water to make up the required amount. He gave the solution in 

 the following doses. 



Lambs 3 months old ^ oimce (22. i7mils). 



Lambs 6 months old iK ounces (44. 56 mils). 



Sheep 12 months old 2K ounces (73. 9 mils). 



Sheep 18 months old 3 oimces (88. 7 mils). 



Sheep 24 months old 3K ounces (103. 5 mils). 



Stiles and others have tested and recommended copper sulphate in 

 these doses. 



It did not appear to the writers that such refinement in dosing was 

 called for in treating sheep; therefore, for the sake of simplicity a i per 

 cent solution was made up and administered in amounts of 100 mils to 

 sheep a year old or older, and in amounts of 50 mils to lambs under a 

 year old. 



Five sheep less than a year old were dosed with copper sulphate, two 

 receiving 0.5 gm. each of powdered copper sulphate in capsule, and three 

 receiving 50 mils each of the i per cent solution. 



The two sheep receiving powdered copper sulphate in a capsule passed 

 a few stomach worms, and on post-mortem showed over 6,000 in one 

 case and over 4,000 in the other. No nodular worms were recovered 

 from the feces, but the post-mortem examination showed over 100 in one 

 case and nearly 200 in the other. Both showed a few tapeworms 

 (Montezia sp.) and hookworms post-mortem, none having been recovered 

 from the feces after treatment. Several other species of nematodes were 

 also found in varying numbers at the post-mortem examination. 



The three sheep which received the copper-sulphate solution passed, 

 respectively, 120, 240, and 314 stomach worms, and showed on post- 



