4o8 Journal of Agricultural Research voi. xii, no. ? 



a perforated cork with a glass tube through the perforation, was inserted 

 in an auger hole. A rubber tube was connected with the glass tube. 

 The keg was placed on a high shelf in the barn and the rubber tube from 

 the bottom of the keg connected with one of two glass tubes that per- 

 forated a rubber cork in the bottom of a graduated glass cylinder, the 

 top of the cylinder being on a level with the bottom of the keg. The 

 graduated glass cylinder was fastened by wires to two nails driven into 

 the wall in such a way as to maintain it in a vertical position. 



A second rubber tube was connected with the second glass tube in 

 this cork, this tube terminating at the other end in a piece of metal 

 tubing. The glass cylinder was graduated at 50-mil intervals and had a 

 capacity of 150 mils. Close to this cylinder, pinch controls were fastened 

 on the rubber tubing leading into and out of the cylinder. By pinching 

 the control on the rubber tube connecting the keg with the glass cylinder, 

 the copper-sulphate solution was allowed to flow from the keg to any 

 desired graduation in the lower cyHnder. By letting this close and 

 pinching the other control, the solution was allowed to flow from the 

 cylinder to the metal tubing at the other end of the dosing tube, the size 

 of the dose delivered being noted on the cylinder. The metal tubing 

 was held in the sheep's mouth by one man, while another man controlled 

 the size of the dose. 



In actual practice, with two men operating this apparatus, as noted, and 

 with a third holding the sheep and a fourth bringing them up, 25 sheep 

 were given 50-mil doses in 15 minutes, and 27 sheep were given loo-mil 

 doses in 25 minutes, a total of 40 minutes for 52 sheep. In the 50-mil dose, 

 which is perhaps enough for sheep of any age, since it combines safety 

 with efficacy, sheep can be dosed at the rate of i ^ a minute. This is 100 

 an hour, or 800 sheep for an eight-hour day. 



It should be noted that of the sheep that received lOO-mil doses of the 

 solution, the equivalent of i gm. of copper sulphate, 2 sheep died in the 

 course of the next two days. These sheep were 10 months old, and these 

 d©ses would appear to be too large. Neither of the dead sheep showed 

 any indications of traumatic pneumonia, but the fourth stomach of one 

 of them was much congested. 



On a subsequent occasion the 50 sheep surviving from this experiment 

 were dosed with 50-mil doses, using the apparatus described. No bad 

 results of any sort were experienced. The sheep have been similarly 

 treated subsequently, and occasional post-mortem examinations of the 

 sheep in this lot show almost complete freedom from stomach worms. 



COPPER SUIvPHATE 



For worms in dogs. — In view of the efficacy of copper sulphate against 

 stomach worms in sheep, an attempt was made to determine whether the 

 well-known emetic action of this drug would entirely prevent its use as 

 an anthelmintic for dogs. Four dogs were each given 0.5 gm. of copper 



