Feb. i8. 1918 Efficacy of Some Anthelmintics 439 



being considerably more efficacious than it was found to be against 

 hookworms in dogs. It was inefficacious for other intestinal worms. 

 On the whole, the use of chenopodium for stomach worms and hook- 

 worms in sheep seems to promise considerable success when properly 

 administered, and is at least worthy of further trial. 



For worms in poultry. — ^To test the efficacy of oil of chenopodium 

 against worms in poultry, six chickens were dosed at a rate of about 

 0.4 mil per kilo. Each bird weighed 0.5 kgm. Each bird received 2 

 mils of castor oil followed at once by 0.2 mil of oil of chenopodium 

 mixed with 2 mils of castor oil, the birds being kept without feed the 

 previous day. The treatment was fairly satisfactory for Ascaridia 

 perspicillum, removing 9 out of 13 worms. In this connection it will 

 be recalled that the experiment in feeding tobacco stems to chickens 

 was carried out with birds not infested with A . perspicillum, so that the 

 writers have no data of their own to compare with the showing made 

 by oil of chenopodium. As already stated, Herms and Beach (1916) 

 found the treatment very efficacious for worms which were evidently 

 Ascaridia perspicillum, to judge from their illustration of the para- 

 sites. 



Chenopodium removed only 2 out of 349 cecum worms (Heterakis 

 papulosa) and was entirely inefficacious against other nematodes. No 

 tapeworms were passed in the feces, but 22 were found post-mortem, 

 2 of which were in the large intestine. Even though these 2 are con- 

 sidered as having been removed by the anthelmintic, the showing is 

 not very creditable. It may be stated, however, that none of the sub- 

 stances tested by the writers for tapeworms on poultry have proved 

 very satisfactory. 



DISCUSSION OF RESULTS 



In order to present the foregoing data in a condensed comprehensive 

 summary, the various experiments have been tabulated by hosts 

 (Tables I-V). These tables show, for each host, the efficacy of the 

 different drugs tested against the more important parasites, as indicated 

 by the percentage of worms removed compared with the total number 

 present. Three columns of figures are given for each parasite, in order 

 that the reader may see at a glance not only the percentage of efficacy 

 but the data from which this percentage is derived, and thus be able 

 to judge how conclusive or otherwise the figures presented may be. 

 The tables also show the number of host animals used for each drua: 

 tested, and the size of the dose, usually based on the weight of the 

 animal. A reference column gives the pagination of the experiments 

 described in detail in the text. Where several experiments have been 

 conducted in testing one drug, the results are combined in the tables 

 into a single set of figures. 



