Feb. 18, 1918 Efficacy of Some Anthelmintics 445 



{1908) that the administration of castor oil after male-fern will avoid 

 the toxic effects of the latter by causing its rapid and thorough elimina- 

 tion, and that for this purpose no other purgative is quite so effective. 

 This subject, however, should receive more study before conclusions are 

 drawn. 



Pelletierine tannate was a failure in the one experiment in which it 

 was tested on cats, but was efficacious on dogs. No remedy was effica- 

 cious against tapeworms in poultry. Of the four drugs tested, chenopo- 

 dium gave the best results for this purpose, but its efficacy for tapeworms 

 is very slight. 



Turpentine proved the most efficacious of the remedies tested on 

 poultry for the removal of Ascaridia perspicillum, while chenopodium 

 was nearly as good. When tested on dogs and pigs, turpentine was not 

 very efficacious; and, as it caused grave symptoms of nephritis in pigs 

 and caused the death of some of the experiment dogs, its use upon these 

 animals is inadvisable. 



The treatment with chopped tobacco stems recommended by Herms 

 and Beach for ascarids in poultry proved fairly efficacious for Heterakis 

 papulosa and would presumably be at least as efficacious for Ascaridia 

 perspicillum, since this latter worm is more easily reached by anthel- 

 mintics than is H. papulosa. 



There are a large number of drugs showing a greater or less degree of 

 efficacy for the various intestinal parasites of domestic animals. Usually 

 their action is selective — that is, they show a pronounced efficacy for 

 certain species of intestinal worms, while they are decidedly less efficacious 

 or entirely inefficacious against other intestinal parasites. If we consider 

 the ideal anthelmintic one which will remove all worms of a given class 

 or species, and do this every time in a single dose, we find that very few 

 drugs approach this ideal. 



Among the drugs which have given the best results under experimental 

 conditions for the purposes intended and concerning which the writers 

 have sufficient data to warrant positive conclusions may be mentioned 

 the following : 



(i) Copper sulphate in drench for stomach worms in sheep. 



(2) Oil of chenopodium for ascarids in pigs and dogs. 



(3) Oleoresin of male-fern for tapeworms in dogs. 



(4) Turpentine for Ascaridia perspicillum in fowls. 



(5) Chopped tobacco stems for Heterakis papulosa in fowls. 

 27810°— 18 i 



