124 Journal of Agricultural Research voi.xix, No. 3 



McCandlish^ reports two series of trials with galactogoges. In the 

 first series one cow was used and in the second there were three. The 

 experimental period covered two days in each series, with a control 

 period of two to four days follov/ing. 



Results as given by McCandlish may be summarized as follows: 



1. On tlie whole, alcohol depressed rather than stimulated miljc and butter fat 

 production . 



2. Castor oil decreased the percentage of fat in milk, btit the changes in milk 

 yield were not appreciable. 



3. Pitutarin treatment resulted in decreased milk and butter-fat yield. 



4. Administration of pilocarpine and physostigmine resulted in an increased fat 

 yield in the first series. One of the cows in the second series showed an increased fat 

 yield, while the other two showed a decrease in milk yield. 



5. The effect of aloes was greatly reduced milk yield and a fat ;yaeld somewhat 

 reduced, but the averages show little change. 



6. A mixture of epsom salts, common salt, and nux vomica showed only slight 

 effect on milk and fat yield. 



THE EXPERIMENT 2 



The experiment was begun April 14, 191 9, and closed July 11, 191 9. 

 The objects of the experiments were: 



1. To determine the effect of various drugs on the butter-fat test of 

 milking cows. 



2. To study the effect on the total fat yield of producing cows. 



3. To determine whether drugs have an effect on the health or on 

 total milk production. 



METHOD 



Four cows of mature age were chosen as experimental animals. No. i 

 was a grade Holstein, No. 2 was a pure-bred Holstein, and No. 3 and 4 

 were pure-bred Guernseys. The interval of experimentation with each 

 drug was five days. A control period of five days preceded all experi- 

 mental periods, except the first five days of the experiment. Each 

 of the four cows received a different drug for a 5-day period. This was 

 followed by a 5-day control period during which no drugs were given. 

 At the end of this period the drugs were shifted so that each cow re- 

 ceived a different drug from the one previously given. Thus the control 

 and experimental periods alternated, and the order in which the drugs 

 were given was so arranged that each cow received each of the eight 

 drugs for a 5-day period. 



The cows experimented upon were milked twice daily, the weight of 

 milk was recorded, and composite samples of the milk from each cow 

 were tested for butter fat daily. 



Drug mixture No. i was recommended to us by a prominent dairy- 

 man. The mixture No. 5 is one recommended by Friedberger and 



' McCandlish, Andrew C. the possibility of increazing milk and butterfat production by 

 THE ADMINISTRATION OF DRUGS. In Jour. Dairy Sci., V. I, no. 6, p. 475-486. 1918. 

 2 Credit is due Dr. C. C. Palmer for administering drug No. 6 hypodermically. 



