wyoscyaMus nicer. ORD. XII. Solanaced; sew Luride. 907 
of the extract, which in several disorders-was often found to pro- 
duce sleep more powerfully than opium. -The success of Hyoscy- 
amus in these cases, (many of which were said to be of long du- 
ration, and to have resisted the effects of other remedies) is also 
confirmed by Collin, who extended the dose of the Extract. Hyoscy- 
mi, to twenty-four or thirty grains per diem.' But from ‘the ex- 
periments made of this medicine by.Greeding, who tried it in forty 
cases of melancholia, mania, and epilepsia,. the result was very dif- 
ferent:* yet while his practice shews that no benefit is to be ex- 
pected in these three diseases, it tends to prove that this medicine 
is a useful anodyne; and as it usually opens the body, it may be 
advantageously substituted for opium, where the astringency of the 
latter becomes an objection to its use. Dr. Cullen’ says, “ that in 
“epilepsy, and various convulsive affections, for which Baron 
« Storck particularly’ recommends thé extract of Henbane, we have 
“very frequently,employed it, but have never found it of any great 
“‘ virtue, nor of more than what we have found in opium. We 
« have indeed found the Hyoscyamus to be often an agreeable ano- 
* dyne and soporiferous medicine; and we have’ frequently found 
“it such in persons, who from particular circumstances did not 
“ agree with opium, and, particularly because it was less-binding to: 
“ the belly than opium. We judge however that it is more ready 
“in full doses to give delirium than opium is, and therefore we 
* found it in many cases io. give tprbulent and nhs pia g sleep; 
« ployed it, we have been obliged’'to ay it aside.” Dr. Withering” 
found it ofigreat advantage ina case of difficult degltitition. Stoerck 
and some others recommend this extract in the dose of one grain or 
two; but Dr. Cullen observes, that he seldom discovered its ano- 
dyne effects till he had proceeded to doses of a or ten: grains, 
and sometimes to fifteen,’ ‘and even to twenty. 
 Observ, Tom. 2, 2 142, k Vide g Aes Advers. Med. pre Pol, iP. tp. 7 ke §, 5g 
1 Mat. Med: vol. tt. p. 271. 
