219 ORD. XII. Solanacee, seu Lurid. wrcotiANa TABACUM. 
« When snuff is first employed, if it be not both in small quantity 
‘‘ and be not thrown out immediately by sneezing, it occasions scme 
‘« giddiness and confusion of head; but by repetition these effects 
“cease to be produced, and no other effect of it appears in the 
“accustomed, when not taken beyond the accustomed quantity. 
«‘ But even in the accustomed, when it is taken beyond the usual 
“quantity, it produces somewhat of the same giddiness and con- 
«fusion of. head that it did when first employed; and in several 
“ cases, these effects in the accustomed, depending on a larger dose, 
“are not only more considerable, as they act on the sensorium, but 
“as they appear also in other parts of the system, particularly in 
“‘ the stomach. occasioning a loss of appetite, and other symptoms. 
* of a weakened tone in that organ. 
“ With respect to this, it is to be observed, that persons who take 
“a great deal of snuff, though they seem, from the power of habit, 
* to escape its narcotic effects; yet as they are often liable to go to 
** excess in the quantity taken, so they are still in danger from these 
“‘ effects operating in an insensible manner; and I have observed 
“‘ several instances of their being affected in the same manner as 
“* persons are from the long continued use of other narcotics, such 
“as wine and opium; that is, by a loss of memory, by a fatuity, 
“‘ and other symptoms of the weakened or senile state of the nervous 
* system, induced before the usual period. 
«« Among other effects of excess in snuffing, I have found all the 
“symptoms of dyspepsia produced by it, and particularly pains of 
** the stomach, occurring every day. The dependance of these upon 
“the use of snuff became very evident from hence, that upon an 
* accidental interruption of snuffing for some days, these pains did 
* not occur; but upon a return to snuffing, the pains also recurred ; 
~ ¢ and this alternation of pains of the stomach and of snuffing having 
“ occurred again, the snuff was entirely laid aside, and the pains 
“did not occur for many months after, nor, so far as I know, for 
* the rest of life. 
« A special effect of snuffing is its exciting a considerable dis- 
Be Seah Pirietgs SAI 
