sestosiediien fruit of Randia dumetorum in er parts. “These 
_ drugs are rubbed down on a stone with the j juice of the Betel 
 pepper-leaf, and made into pills, the size of the seed of Abrus 
precatorius (about 2 grs.). The.dose is one pill every five 
_ minutes rubbed down with Betel-leaf juice until three pills 
have been taken. European physicians in India have long 
been in the habit of using Bish as a substitute for ordinary 
- asource of Aconitine. -As far as our experience goes it is not 
_ more dangerous than the mixed reots known in the European 
markets as German Aconite; a supply of Aconite of known 
_ botanical origin is still a desideratum in pharmacy. Modern 
physiological research shows that Aconite applied externally 
1 acts as a local irritant and narcotic, producing numbness and 
’ _ tingling. Introduced into the circulation in large -quantity it 
_ causes sudden paralysis. of the heart-muscle, which appears 
_to be due to the action of the poison ‘upon the vagus roots }. 
r, but poisonous doses, cause disturbance of the respi- 
E F sidnoular weakness, vascular depression, and death. 
4 Pr hovapentio doses cause reduction of the force and frequency 
_of the circulation, muscular inertia, and slight tingling in the 
_ extremities or Sti: Similar effects are Sr cdachd in man and 
in animals. Numérous experiments “have been made to 
ascertain the manner in.which Aconite influences the heart, 
but further investigation i is still required to settle this point. 
been used with success in cases of poisoning by aconite; they 
of the poison as the vagus roots. 
q Aconite root, and it has of late years been used in Hurope as» 
_RANUNCULACEZ. , 30 
and nerves and upon the heart. Atropine and Digitalis have 
appear to restore the power of the heart. by oe ber S 
effec as 
