a. ee PAPAVERACEZ. | 
are severe headache, with nausea; furred tongue, and loss oy 
"appetite. During the stage of sleep ‘the brain is anzemic, both 
the arteries and veins being’empty. With large doses the first 
' stage is very short. Sleep rapidly *follows, becoming dee 
and deéper, and passes into coma, from which the patient ca 
longer be aroused. The pupils become’ very much contrac 
and the pulse from slow and full, becomes -feeble. Fin: 
‘death by asphyxia occurs, the. respiration ceasing before 
heart. It may occasionally be preceded by convulsio 
though this is- rare, Upon: post-mortem examination 
ordinary appearances of death by asphyxia are found. (Le 
Brunton.) ; 
Although the symptoms which have been narrated are th 
usually produced by opium, yet in certain individuals the 
_ provokes quite different phenomena, One of the most ¢ 
next dose. It has 
he effects of the drag. - ' 
