436 . . LEGUMINOS 
the residue was a yellowish-brown, amorphous powder, con- 
sisting of coagulated globulin and unaltered albumose. 
Physiological Action of the Proteids of Jequirity.*—For sub- 
cutaneous injection and for instilling into thé eye a-solution © 
of the proteids was made. The globulin was dissolved in 15 
per cent. sodium chloride solution, and the albumose in dis-' . 
tilled water or normal saline solution (0°75 per cent. NaCl), 
Previous to using these liquids or solvents, they were well 
boiled to sterilise them, and then cooled. A weighed quantity 
of the prcteid was then- dissolved and used in the experiment; 
or a solution of the proteid was made, and the quantity pines 
was estimated. 
Local Action on the Eye.—A watery infusion of the eo 
when instilled into the eye produces, as is well known, severe 
inflammation with purulent discharge; and it is this action 
which is both beneficial in the treatment of granular lids and of 
pannus. Both the globulin.and the albumose of jequirity possess 
this property. Thus in one experiment 2 milligrams. of the solid 
globulin (containing some coagulated proteid) wereplaced on the 
inner surface of the left eyelid of a large rabbit. In seventeen 
hours and three-quarters the conjunctiva was reddened and 
slightly swollen; there: was no chemosis, but there was a clear 
serous discharge. In twenty-four hours, there was intense — 
purulent ophthalmia, with subcdnjunctival ecchymosis: the — 
cornea being quite clear. The purulent discharge lasted till _ 
the death of the animal, eighty-three hours after inoculation; 
the animal being apparently ill for about four hours before 
death. At the post-mortem, there was. severe subconjunctival, 
hemorrhage, with cedema round the eyeball. If the dose be 
- smaller, the animal does not die after eye inoculation, nor does — 
it suffer from any general symptom; but local inflammation — 
and cedema with purulent discharge always follow in about — 
sixteen or seventeen hours, ‘ 
“* The action of the globulin was investigated in co-operation with me 
Wolfenden ; for the account of the albumose I alone am responsible. Th 
results are ee SS Ore REare Bron, ee Soc., ied 1889, 
