‘MYRTACEZ. 37 
, 
3 
Dri ©. Graeser, of Bonn, has published in the Centralblait 
fiir Klinische Medicina highly-interesting account of a series of 
experiments with the extract of the fruit of Syzygium Jambola- 
num on dogs, which had previously been made diabetic by the 
administration of phloridzin. 
Dr. Graeser thought that the best way of studying the phy- — 
siological and therapeutic action of the new drug was to admin- 
ister it to dogs which had artificially been made diabetic by a 
method introduced by V. Mehring, who found that artificial 
diabetes can at any moment be produced in dogs by the admin- 
istration of phloridzin. 
A young dog of 2,700 to 4,800 grammes body weight, to 
which 2°5 to 4°8 grammes of phloridzin (1 gramme to 1 kilo 
body weight) have been given, in the course of a day will show 
an excretion of sugar, lasting for twenty-four tc thirty hours, 
and amounting to 5°89 to 12-45 grammes. Graeser first gave 
_ the daily dose of phloridzin, but later on he split the quantity 
into doses of 1 gramme, given every two to three hours. In 
both cases the excretion of sugar was the same. Diarrhoea 
was caused by phloridzin in three cases. After “Graeser had 
experimented for some time with phloridzin alone he began to 
| administer simultancously phloridzin and extract of Syzygium 
_ Jambolanum. The latter was given before, along with, or after 
phloridzin, and invariably had the effect of reducing the 
expected excretion of sugar most considerably. This reduction 
_ amounted to at least half, in some cases even to nine-tenths, of 
_ the quantity of sugar which would have resulted had phloridzin 
' alone been given. At the same time the duration of the dia- 
_ betes was shortened. Dogs, which under phloridzin alone had 
_ excreted 5:89 to 12°45 grammes of sugar, showed under the 
_ jambul treatment a maximum excretion of 2:906 grammes of — 
_ Sagar, and a minimum excretion of 1-5 gramme. 
_ 4As jambul showed such a powerful effect on the avtificialtysd ay 
_ produced diabetes, it may be anticipated that when given ab) 
_ the proper time and ina dena dose it will —— patie ae 
: excretion of sugar, ; 
