28 MYRTACEA!. 
It is not yet known how jambul given in large doses acts on 
the pathological diabetes mellitus of man. But it is well worth 
trying. The experiments on man are all the more justified as 
no ill effect has ever yet been produced by the new drug. 4 
_ favourable effect of such experiments would prove that phlorid 
zin diabetes and pathological diabetes are of a similar nature. 
In all the animals on which Graeser experimented no signs 
of any secondary effects of jambul extract were observed, not 
even after doses of 18 grammes. In one case diarrhcea set in, 
which, as further experiments proved, was caused by phloridzin 
and not by jambul. 
_All his experiments were made with extract of jambul pre- 
pared by Mr. R. H. Davies, F.1.C., chemist to the Society of 
Apothecaries, London, from seeds which the author had him- 
self brought over to Europe. As the fruit contains great quan 
tities of starch, it was thought advisable to eliminate this a 
much as possible in preparing the extract. Several extracts 
were prepared out of the whole fruit, or solely out of the kern 
or solely out of the pericarp ; 100 grammes of the fruit gav 
16} grammes kernel-extract, and 11% grammes pericarp extrac 
The most given in one single dose was 6 grammes, the m 
mum daily dose 18 grammes. 
_ Whether the active principle is contained in the pericar 
or kernel cannot as yet be decided toa certainty, Proba 
it is contained in both, but to a greater extent in the pericarp. 
From the long series of experiments which he has mad 
Graeser draws the following conclusions :— Lee 
~ 1. Phloridzin diabetes is considerably lessened by jamb | 
extract. ' 
2. Jambul extract is non-poisonous, and does not 
ill effect. 
3. The active principle contained jin jambul is not - 
known. It will have to be determined by carefal analysis 
further experiments. (Chem. and Pruggist 1889.) Ses 
With reference to Graeser’s experiments, G. I, Tay 
(Vratch., 1889, p. 1029,) records having obtained neg 
cause an 
