RUBIACE E. 497 
gs. For further information the reader is referred to 
eruvian Bark,” by C.. R. Markham; “ Cinchona Barks 
harmacognostically considered, ” by F, A. Flickiger; Blue 
Books. Copy of Correspondence relating to the Introduction of 
the Cinchona Plant into India, Sc., with Maps. 1852 to 1875, 
5 volumes; The Annual Reports on the Government Cinchona 
Plantations, Bengal and Madras, up to 1889. 
Small doses of cinchona preparations and quinine aug- 
ment the force of the heart’s constriction, increase the 
“appetite, and act as a general tonic, but if too frequently 
repeated, the contractile power of the heart is diminished, 
hough the rate of its movements progressively increases ; 
he latter effect is also produced by large single doses. 
isonous doses annihilate the heart’s contractility, producing 
rapid death; yet if the operation is not promptly fatal, the 
“respiratory movements cease before those of the heart. Theo- 
-retically, in moderate doses, quinine stimulates the trophic 
centres, and quickens tissue change, but in large doses it has 
The reduction of the pulse rate and force . 
quinine is attended by a reduction in temperature. — Obser- : 
e 
ains of sulphate of quinine are taken by an adult man at a 
gle dose, or two orthree times that quantity in the course of 
hours, there is apt to be some heaviness and confusion of 
hought, headache, buzzing in the ears, vertigo, and unsteadi~ 
of gait. Larger doses occasion, in addition, a sense of — 
fulness, tension, and pulsation in the hea d; the face becomes : 
suffused and animated ; the eyes are beehes epistaxis some- 
imes occurs ; the patient is restless and agitated, and com- 
ins of sGuvecain twitching in the limbs. After several — 
jours these phenomena are followed by some degree of exhaus- — 
ion and a disposition to sleep, with slight torpor ‘and mus-_ 
ular debility. Ifas much as 30 grains are given daily for 
eral es in divided doses there. simecd pene: 
