APOCYNACEA. 407 
“Their. trials with it in various forms of remittent fever 
proved highly satisfactory, and leave: little doubt that it is a 
‘remedy of considerable power. It was.employed in the form of 
‘tincture (one ounce of the freshly-dried bark macerated for 
eight days in 5 ounces of rectified spirit) in doses of from 10 
‘to 15 drops thrice daily. In larger doses (30 to 60 drops), it 
‘acts as an acrid purgative and emetic, and carried to a greater 
extent is evidently powerfully poisonous, The kernels are 
‘extremely bitter, and when chewed produce a slight feeling of — 
numbness and heat in the tongue; by expression they yielda — 
clear, pale amber-coloured, slightly viscid, acrid oil, which is 
‘sometimes recommended as a cathartic by the natives, but, 
‘according to Dr. Shortt, it produces vivlent vomiting and 
‘hypercatharsis. (Pharm. of India, p. 188.) This, however, is 
‘contrary to our experience; the oil when pure is as inert as 
‘olive oil. 
- Dr. A. J. Amadeo of Porto Rico states that two- grains of 
‘the extract of the bark, given in the apyrexia of intermittent 
fever, prevent the access of the paroxysm, and that the natives 
employ the bark in infusion for the cure of ague. ee 
April, 1888.) 
‘The active principles of the Sait? Thevetin and Thevenviin 
have been thoroughly tested in experiments on animals by 
as and by T. Husemann (Archiv fiir exp. Pathol. u. Phar., Vv 
228). The former has upon frogs the same effects as digi- 
Voluntary motion is not 
y , although riety is ieapeired:i in the hindlegs. The 
, essentially, were produced by theveresin in the 
0°05... Experiments upon dogs and rabbits led 
siren peer: a abenng: spe bein i : 
