LOGANIACEM. 463 
poison through the integhment: ‘It is well known in India that 
birds are comparatively insusceptible to the poison, and large 
_ doses of nix-vomica may be given to fowls without any injuri- 
ous effect.” Ruminating animals ave less easily affected by strych- 
nine administered with the food than other quadrupeds; dogs 
and rabbits are soon destroyed by it, whilst certain monkeys and 
some other animals are said to be comparatively insusceptible to 
its action, Injected into the circulation it probably affects all 
animals alike. . Stillé.and Maisch remark :—* The phenomena 
fin the various cases in which its specific operation is developed 
donsists of tremor, twitchings, and startings of the voluntary. 
7 tauscles, followed by tetanoid spasms, during which the heart’s 
Action i is accelerated, the temperature raised, and the respira= 
tion and. consciousness suspended. Between the spasms the cir~ 
elation generally becomes normal, the consciousness returns, 
and cutaneous hyperasthesia is observed, but the spasms may 
renewed by any excitation, as a touch, a loud sound, or @ 
den impression on the eye.. Death may occur through. 
hy xia from tonic spasm of the tespiratory muscles, by 
yn syncope, or .by exhaustion.’ The heart continues to pulsato 
fter the respiratory 1 movements have ceased.. Of these modes’ 
of death, that during spasm is by far the most — frequent i in’ 
eases of strychnine-poisoning. No lesion’ is ‘anifornily found 
after déath; the heart- may be distended with black blood or 
enipty, and, although congestion and serous effusion within the: 
ninges of the brain and spinal cord are usual, they are _ 
uniformly met with, and in the substance of these organs no 
-chatacteristic: alterations have been observed. Falck experi- 
‘™mented on: rabbits with brucine nitrate injected subcutan- 
eonsly in doses from *l gram: to.-02 gram. per kilogram of 
body weight. He found that the —- maria sng be 
arranged i in three divisions :—: ” 
1 1st—Respiration is quickened, and in some cases a strange 
injection of the éar was noted : the pupils may be dilated,... reste) 
onetpammieg Soong ——* magaraerct sed 
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Feta ere I Means SRS het ae 
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