SOLANACE®. 629 
sopor to arouse the sleeper, but uselessly. During the sleep 
the muscular system was completely rélaxed, and the pulse 
at first was full and hard, 138 a minute, the respirations 
34 to 40, and the temperature 106° F. As the narcotism 
’ subsided these rates subsided rapidly toward the normal stan- 
dards. Onregaining consciousness the mind was unsteady and 
confused, and all objects looked tinged with yellow. During 
the sleep there was more or less nausea, and once vomiting. No 
recollection of anything after the commencement of sleep 
remained. For several days the pupils remained dilated, and 
there was double vision, while all the secretions, including the 
perspiration, were suspended. A patient of Empi’s affected 
with paralysis agitans took 5 mgm, of hyoscyamine (gr. 7g), 
and, finding the tremor diminished, used a like quantity on the 
following day. The first dose caused a slightintoxication, and 
after the second there was a like confusion of the mind and senses; 
. the face was flushed, the expression anxious, the whole interior 
_ of the mouth dry, the tongue stiff, and nausea was experienced. 
Hallucinations in which rats and serpents appeared, and familiar © 
_ persons were not recognized, were accompanied and followed 
by furious delirium, tetanic spasms, and extreme dilatation of 
the pupils. Deglutition was impossible; the respiration was 
hurried and oppressed, the pulse at 96; and constant vesical 
tenesmus existed. The attack lasted for 3 hours, and gra- 
dually subsided, and on the morrow only some recollection of 
the hallucinations remained. (Bull. de thérap., xcix. 373.) A 
phthisical tg accustomed to hypodermic injections of mor- 
phia was given 7; grain of hyoscyamine. After vomiting he 
became delirious, lost all correct perception of the distance of 
objects, and constantly caught at insects, with which he said 
his bed-clothes were covered. (Practitioner, xxii. 369.) In 
some forms of hypochondriasis hyoscyamine seems to have 
been useful as a means of calming agitation. Prolonged 
experience has confirmed these statements. Prideanx states 
(Practitioner, xxiii. 446) that it produces sleep, sometimes of 
’ wonsiderable duration, in excited conditions of the brain, as in 
‘a. delirium tremens, meningitis, and where ordinary 
