SOLANACHEE. 637 
stimulates the spinal cord, giving rise’ to convulsions and after- 
wards paralyses it. ‘The convulsions are of spinal origi im the 
frog, but those which occur before death in mammals are 
probably asphyxial. (C. Bernard, C. Rouget, L.-Brunton.) 
~ Onman the minutest doses of nicotine(.7; to zy grain) occasion 
a burning sensation in the tongue, a hot, acrid feeling in the 
fauces, and sense of rawness throughout the cesophagus. 
- Salivation is abundant. Small doses produce a sense of heat 
‘in the stomach, chest, and head, and even in the fingers, with 
some excitement of the nervous system; larger ones cause 
heaviness, giddiness, torpor, sleepiness, indistinct vision, with 
‘sensitiveness of the eye to light, imperfect hearing, laborious 
‘and oppressed breathing, and dryness of the throat. In 40 
minutes after the larger doses a sense of great debility: is 
ceived, the head droops, the pulse-rate falls, the face grows 
, the features are relaxed, the limbs seem paralyzed, the 
hands: and feet are cold, the coldness advances gradually 
trunk, and faintness ends in loss of consciousness. 
oe 
lisor or of the digestive organs manifests itself by 
18, mnauseay and even vomiting, the abdomen becomes 
nded, and an urgent desire is felt to go to stool ; wind i is 
| “tremulousness of the ceiuunbees and gradually Ee aa 
whole muscular system, including the respiratory muscles, 
that the breathing is oppressed, gasping, and incomplete. 
This enumeration of effects is sufficient to prove that nicotine 
inal and sympathetic nervous systems, 
It may cause death by direct paralysis 
eart, or more indirectly by paralysis of the respiratory 
producing asphyxia. The blood examined during life _ 
rson under the full influence of tobacco presents & — 
cor gation of the red corpuscles, which are also 
reular than natural, and have jagged or, crenated 
As we poisonous operation passes off, however, the 
primarily upon the sp 
nd not upon the brain. 
