100 APPENDIX. 



action upon rabbits. Cats were very susceptible to the .poison, 



death following three days after the subcutaneons injection of 0-001 



gi-am. In these animals, 2 to 3 hours after the injection violent and 



repeated vomitings occun*ed, at first of food, and afterwards of mucus 



tinged Avith bile, and containing some intestinal worms ; there was 



also obstinate diarrhoea. Finally the animals became dull, the 



temperature fell, the limbs were paralysed, and death occurred 



from exhaustion. Bogs, pigeons^ and fowls were similarly 

 affected* 



The post-mortem appearances observed were intense irritation, and 

 sometimes abscess at the seat of the injection, the stomach normal or 

 slightly injected, the upper portion of the mucous membrane of the 

 duoJenum highly injected, especially round the opening of biliary 

 duct, the lower portion covered by a mass of brown epithelium 

 mixed with detritus and mucus ; the loAver part of the small intestine, 

 and the whole of the lai'ge intestine, was covered by hsemorrhagic 

 patches, and here and there by a membranous exudation, with intense 

 inflammation of the adenoid tissue, the sub-mucous and muscular 

 layers not being affected. Liver congested, gall-bladder swollen 

 and full of bil^. Kidneys congested, with marked glomerulo- 

 nephritis and commencing tubular nephritis. The distended gall- 

 bladder and injection of the duct appearing to indicate elimination 

 of the drag through the liver, the author tied the latter in three of 

 the dogs experimented upon, and afterwards injected podophyllotoxin 

 beneath the skin ; the results were exactly the same as in the case of 

 the dogs not previously so treated. 



Injections of podophyllotoxin into the veins gave exactly the same 



results as when it was administered internally or injected sub- 



cutaneously. The circulation, respiration, and nervous system were 



only affected a little before the fatal 



, experimented upon. 



From these experiments the author concludes that the drag acts 

 as a simple irritant, and that its purgative action when given in- 

 teraally is due to irritation of the intestinal canal. When injected 

 under the skin or into a vein, it is eliminated by the blood through 

 the kidneys and intestine, and in its passage through these organs it 

 sets up the irritative action already described. 



termination in all the animals 



