JOURNAL 



OF THE 



Elisha Mitchell Scientific Society 



VOLUME XXXI DECEMBER. 1915 No. 3 



THE VASCULAR RESPONSE OF THE KIDNEY IN 

 IN ACUTE URANIUM NEPHRITIS— THE IN- 

 FLUENCE OF THE VASCULAR RESPONSE 

 ON DIURESIS^ 



WiM. deB. MacNidee 



From the Laboratory of Pharmacology of the University of N. C. 

 Received for publication, May 30, 1914 



Synopsis 121 



Introduction and review of previous experiments 121 



Discussion of the technique employed in the experiment 123 



The vascular response of the kidney in acute uranium nephritis... 126 

 The pathology of the kidney in animals nephritic from uranium, 

 which following an anesthetic either remain diuretic or 1)ecome 



anuric 136 



Discussion 142 



Conclusions 144 



INTRODUCTION AND REVIEW OF PREVIOUS EXPERIMENTS 



The following investigation, which has primarily as its 

 object a study of the vascular response of the kidney in acute 

 uranium nephritis, serves as the concluding number of two 

 other papers which have appeared in this journal (1 and 2). 



The previous articles have been concerned with the effect 

 of different diuretics in acute uranium nephritis and with 

 the part played by the anesthetic employed in the experi- 

 ments in determining the efficiency of the nephritic kidney. 



In the experiments which have been referred to, there 

 was constantly associated with the development of an anuria, 

 or with a condition approaching anuria, histological evidence 



nicprinti^d from The .foiininl of I'linrmacoloffij and Experimental Thera- 

 pi'iiticK. Xn\. VI, No. 1. Soptomhor, 1014. Presented in abstract before the 

 Soc-ietv for Pliarmacolosv and Experimental Therapeutics, Philadelphia, De- 



*^ cembei- L".). lit 13. 



TZI .\ided by a srrant from tlie fnnd for Scientific Research of the American 



^^ Modi(ral .Association. 





( 121) 



