1915] Kidney Respoxsk ix TTraxiu:m jSTepiikitis 



123 



and 2) which have been made concerning the relation which 

 exists between the degree of epithelial damage and the effi- 

 ciency of the nephritic kidney, the following experiments 

 have been undertaken in the hope of ascertaining which ele- 

 ment of the kidney, vascular or epithelial, is most concerned 

 in the establishment of an anuria. 



The following investigation is, therefore, concerned with 

 the group of animals nephritic from uranium which follow- 

 ing an anesthetic become anuric (Group II) and also with 

 other animals that will serve as control experiments (Groups 

 I and III) which are nephritic from the same quantity of 

 uranium yet following an anesthetic do not become anuric. 



A study of the vascular response of the kidney, the influ- 

 ence of the vascular response on diuresis, and the pathology 

 of the kidney in these anuric and diuretic animals will fur- 

 nish the material for this investigation. 



DISCUSSION OF THE TECHNIQUE EMPLOYED IN THE 

 EXPERIMENTS 



In conducting the experiments two types of anesthetics 

 have been employed : Grohant's anesthetic and morphine- 

 ether. 



Depending upon the type of anesthetic used in the experi- 



Tabl?: I 



Group I. Control cxpcrimoits — Grchant's anesthetic. The vascular 



response of the kidney in anitnals remaining diuretic, following 



Grchant's anesthetic 



