1915^ KiDXEY Kespoa'sk i^- Uraa^ium Nephritis 125 



animals in the series which receive morphine-ether. All of 

 the animals of the- last group were diuretic at the beginning 

 of the experiment. During the course of the experiments 

 two of the animals became anuric. 



All of the animals employed in the experiments were 

 given subcutaneously 6.7 mgni. of uranium nitrate on two 

 successive days. At the end of forty-eight hours following 

 the initial injection of uranium the animals were anesthe- 

 tized and employed for physiological study. 



In these experiments the percentage of glucose in the 

 urine and apparently the severity of the albuminuria were 

 largely dependent upon the age of the animal. The changes 

 in the urine from uranium and the influence of the age of the 

 animal in determining the severity of these changes have 

 been discussed in a previous publication (2). 



During the course of the experiments the changes in 

 general blood pressure were obtained from a canula in the 

 carotid artery. The blood pressure changes and the changes 

 in the heart volume were recorded simultaneously by an 

 ordinary mercury manometer and a Hlirthle manometer. 



The changes in kidney volume were determined by using 

 the following method: The left kidney was constantly em- 

 ployed for the observations. It is more accessible than the 

 right kidney and, therefore, necessitates less handling during 

 its arrangement in the oncometer. The kidney was not de- 

 capsulated. Without the fat being dissected away from 

 around the renal vessels the kidney was placed in a copper 

 oncometer. Within the oncometer the kidney rested on and 

 was surrounded by a thin rubber bag filled with water. Lead- 

 ing from the rubber bag was a rubber tube which could either 

 be connected with a piston recorder, that indicated the 

 changes in kidney volume along with the blood pressure 

 changes on the kymograph tracing, or it could be connected 

 with a water manometer whereby the changes in kidney vol- 

 ume could be indicated in millimeters of water. Both of these 

 methods were employed with each animal. 



The changes in kidney volume when the piston recorder 



