120 Julj:.\al of thk Mitciiki^l Society \ Dec. 



was used were obtained in millimeters by measurinc; the rise 

 or fall in the lever from the normal point that it had pre- 

 viously indicated on the tracing. These changes in volume 

 will be indicated by the use of -f" and — signs. 



During each experiment one observation was made on the 

 effect on urine flow of an exaggerated constriction of the 

 renal vessels, b}' inducing the constriction while the kidney 

 volume was increasing from the use of caffein which had in- 

 duced a dilatation of the kidney vessels. With this exception, 

 after the use of any substance which altered the volume of the 

 kidney, time was allowed for the lever of the piston recorder 

 to regain its normal point, 'lliis was determined by measur- 

 ing the distance between the lever and the base line. 



The substances which were employed to test the response 

 of the renal vessels were caffein for its peripheral dilator 

 effect, and adrenalin for its peripheral constrictor effect. The 

 caffein was employed in the dose of Ice. per kilogram or a 

 1 per cent solution, while adrenalin was used in the dose of 

 1 minim of the 1 — 1000 solution. (Parke, Davis and Com- 

 pany). Two cc. of the adrenalin solution which was used 

 was equivalent to 1 minim of the 1-1000 solution. 



The caffein and adrenalin solutions were given to the ani- 

 mals intravenously, the femoral vein lieing employed for the 

 purpose. 



A canula was placed in the right ureter and the flow of 

 urine recorded in the usual way on the tracing. 



THE VASCULAR RESPONSE OF THE KIDNEY IN ACUTE URANIUM 



NEPHRITIS 



The vascular response of the kidney nephritic from uran- 

 ium has been studied in nineteen animals. Thirteen of the 

 animals have been anesthetized by Grehant's anesthetic lu 

 60 per cent strength, while the renmiiiing six animals have 

 received morphine ether. 



As a result of the effect on kidney function of the nephro- 

 toxic substance plus the effect of the anesthetic there are 

 three groups of animals in which the response of the kidney 



