128 JoriJ.XAL OF TllK ^IlTClIK-LL S( K'l K'l' V I I) 



ec. 



vessels and the iiiriuenec of this response on diuresis, should 

 be studied. 



Group I (table 1) includes those animals which following 

 Grehant's anesthetic have remained diuretic. 



Group II (table 2) includes those animals which follow- 

 ing Grehant's anesthetic have become anuric, while Group III 

 (table 3) represents those animals which followino- morphine- 

 ether have remained diuretic. 



As will be seen by referring to the diiierent tables which 

 are to follow, there are animals in Group I and in Group III 

 which are diuretic at the beginning of the experiment, but 

 later developed an anuria. The explanation for the gradual 

 development of an anuria which is illustrated by these ani- 

 mals will bo considered in the general discussion of the ex- 

 periments. 



All of the animals in the different groups received the 

 same quantity of uranium nitrate per kilogram. The study 

 of the vascular response of the kidney was commenced in each 

 experiment forty-eight hours after the initial uranium in- 

 jection. The duration of the action of the nephrotoxic sub- 

 stance was, therefore, the same in all of the experiments. 



All of the animals of the different grou])s were diuretic 

 on the day of the experiment. 



Group I. Control Experiments 



Grehant's anesthetic. The animals in this group were 

 either young adult animals or puppies varying in age from 

 four to seven and one-half months. 



Following Grehant's anesthetic in 60 per cent strength all 

 of the animals with one exception remained diuretic. The 

 animal which served as the exception became actively diuretic 

 caffein (experiment G, table 1). 



The members of this group have shown a vascular re- 

 sponse from caffein which varied between a minimum vaso- 

 dilation of +32 mm. to a maximum vasodilation of +89 

 mm. (tracing 1, table 1). 



In all of the experiments, with one exception, following 



