i;j(i -loi u.\A]> 111' I 111-; Mri(iii;i.i, Sociiyrv \ Pec. 



fall in kidney volume varying between the extremes of — 16 

 mm. to — 72 mm. (tracing 4). 



From the brief summary whicli has been given of the 

 vas?nlar response of the kidney in these diiferent groups of 

 animals and from a survey of the accompanying tables it will 

 be seen that the vascular response of the anuric group of 

 animals (Group II, table 2) to both caffein and adrenalin is 

 comparable in its degree to the vascular response which has 

 been obtained from these substances in the control group of 

 animals (Groups I and III). 



In the control groups, with two exceptions, a vasodilation 

 from caflein has l)een accompanied by an increase in the flow 

 of urine, while in the anuric group (Group TI) a vasodilation 

 as great or greater than the vasodilation obtained in the above 

 mentioned groups has had no etl'ect in establishing a flow of 

 urine. 



It would, therefore, appear that the condition of anuria 

 is not dependent upon any lack of response on the part of the 

 renal vessels and also that diuresis from calfein is dependent 

 upon some mechanism in th(^ kidney otlier than a responsive 

 vascular mechanism. 



THE PATHOLOGY OF THE KIDNEY IX AXIMALS XEPIIRITIC FROM 



URANIUM WHICH FOLLOWING AN ANESTHETIC EITHER 



KE:\rAIN DIURETIC OK BECO^fE ANURIC 



When the animals which have been employed in the pre- 

 viously discussed experiments are classified from the stand- 

 point of the pathological changes developing in the kidney, , 

 the animals in Groups I and III which have remained diu- 

 retic following the difl'erent anesthetics are found to present 

 a pathological response which in general is similar; while 

 those animals which have become anuric, Group II, show 

 changes in the kidney of the same character but of sufflcieut 

 difi"erence in degree to separate them from the diuretic 

 groups of iiniiiuils.- 



= .V detailed account of tlic pathology of tho kidney in animals either anuric 

 or diuretic. followiPK different anesthetics will he found in tlie .Tour. Med. Re- 

 search, xxviii. .■;. un."i. 



