138 



Jorij.xAL OF iiiK M rrciiKi.i, Socikty 



\Dec. 



tian and O'Hare (6) as occurriiiii' in the alomeruli of rabbits, 

 nephritic from uranium. In a later communication by 

 O'Hare (7) tlie relative difficulty is shown of inducing in the 

 dog glomerarular lesions of a degenerative character. 



The point of difference which serves to separate patho- 

 logically the diuretic from the anuric animals consists in the 

 difference in the degree and extent to which the epithelium 

 of the kidnev has become involved. 



Fig. 2. Experiment 1, T.\bi,k 2 



The figure represents the kidney of an animal anuric following 

 Grehant's Anesthetic. The epithelium of the tubules sliows extensive 

 necrosis. The lumen of the tubules have become obliterated by the 

 swollen epithelium. The glomerular changes are similar to those 

 shown in Figure 1. The renal vessels were responsive to peripheral 

 stimuli. 



In those animals which are found in (n-oups I and III 

 that remain diuretic following an anesthetic the degree of 

 epithelial damage is slight (figs. 1 and 3). 



The epithelium of the convoluted tubules is histologically 

 well preserved. Both the cytoplasm and nuclei of these cells 

 etain well. The cells either show no swelling or the degree of 



