1915] Kir)XP:y Response: i.x ITran^ium Nephritis 141 



of fat. The fat, when stained by Herxheimer's Scharlach R 

 method, appears in the form of coarse granules or large 

 masses. 



In Groups I and III there are animals which after an 

 initial period of diuresis become anuric (experiment 6, 

 Group I, table 1 and experiment 6, Group III, table 3). 

 These animals have shown a vas3ular response to both caifein 

 and adrenalin, which in degree is comparable to the vascular 

 response of animals in the same groups that remained diu-' 

 retic. They differ, however, from the diuretic members of 

 the group in that the degree of epithelial involvement of the 



Fig. 5 



Figure 5 represents the remaining kidney of the same animal after 

 the animal had been subjected to Grehant's Anesthetic for one hour. 

 The epithelium is severely swollen and shows an extensive necrosis. 

 As a result of these changes the lumen of the tubules has become 

 obliterated. The animal was completely anuric. 



Figure 4 should be compared with figures 1 and 3, and figure 5 

 with figure 2. 



kidney is much more pronounced than it is in those mem- 

 bers remaining diuretic. 



It would appear, therefore, that the gradual development 



