144 ,lurj£.\AL OF iiiK AlriciiKi.L SociKTY [JJec. 



consisted in degenerative cbani>es in the epithelium of the 

 tubules and principally in the epithelium of the convoluted 

 tubules. These dei>enerative chaniics which may, or may not 

 be associated with an acute swelliui;' of the epithelium, termi- 

 nate in necrosis. 



COA^CLUSIOA^S 



1. When caffein is given to an animal nei)hritic from 

 uranium with an epithelial element histologically intact, fol- 

 lowing a rise in kidney volume from the vasodilation induced 

 by the caffein there is an increase in the flow of urine. 



2. When however, caffein is given to an animal ne- 

 phritic from uranium with an epithelial element which is in 

 various stages of necrosis, there is no change in the rate of 

 urine flow even though the vascular response from the caffein 

 may be as great as or greater than the vascular response in 

 the animals in which the cafl'ein was of diuretic value. 



3. From the observations which have been made in the 

 present investigation it would appear that the functional ca- 

 pacity of the kidney nephritic from uranium is more depend- 

 ent upon an intact epithelial element than it is upon a re- 

 sponsive vascular mechanism. 



BIBLIOGRAPHY 



(1) AlacNider: Jour, of Pharm. and Exper. Ther., iii, no 4, 1912. 



(2) MacNider : Jour, of Pharm. and Exper. Ther., iv, no. 6, 1913. 



(3) Schlayer and Hedinger : Deutsch. Arch. f. klin. Aled., xc, no. 

 1907. 



(4) Pearce, Hill and Eisenbrey : Jour. Exper. Aled., xii, no. 2, 1910. 



(5) Christian: Boston Aled. and Surg. Jour., clix, no. 8, 1908. 



(6) Christian and O'Hare : Jour. A/Ied. Research, xxviii, no. 1, 1913. 



(7) O'Hare: Arch. Int. Med., xii, 61-63, 1913. 



