October, '14] townsend: verruga and PHLEBOTOMUS 363 



dom of movement. Smears of September 26, 29, October 4 and 10 

 show Bartonia bodies. Smears also show leucocytosis beginning Sep- 

 tember 18 and gradually increasing to September 24, with a lapse to 

 normal September 30 to October 9, appearing again slightly till October 

 14. Temperature average for thirty days foUowdng September 18 

 was 39°, reaching 40° on September 26, 40.6° on October 9, and remain- 

 ing continuously close to 40° from September 23 to October 2. Weights 

 showed quite steady gain from 3,472 on September 19 to 4,200 on 

 October 14. No visible external eruption has yet appeared. This 

 seems another case of a resistant animal phagocyting the verruga 

 organisms. The experiment is the most ambitious one that it was 

 possible to try at that season with the living Phlebotomus. 



Experiment XXVI 



Canis caraihicus, male, about 2 years, from Chosica. Admitted to 

 laboratory August 18. Average temperature under 38.5°. Normal 

 weight about 7,000. Very healthy, sound, smear showed blood normal 

 before experiment. Injected subcutaneously September 4 with 50 

 Phlebotomus in physiological solution. Smear of September 7 shows 

 Bartonia bodies. Leucocytosis is shown in smear of September 13. 

 Temperature averaged 39.5° for the ten days succeeding September 6, 

 reaching 40° on September 10 and 14, and being close to 40° from Sep- 

 tember 9 to 18. Weights showed fall only on September 7 and 8 of 

 300, and September 18 of 700, with these exceptions rising quite stead- 

 ily from 6,550 on September 5 to 6,750 on September 17, but passing 

 7,000 on September lO.and 13. Up to October 16 dog had been quite 

 normal and no external eruption had appeared. On latter date in- 

 jected subcutaneously in right shoulder with strong dose of virus from 

 nodular verrugas of man. This injection produced a marked effect, 

 animal becoming dangerously ill and weak, with great pain and ten- 

 derness in right shoulder, where an immense abscess formed at point 

 of injection involving the entire scapular region, these conditions 

 continuing from October 18 to 23, when the abscess broke, and the 

 dangerous effects persisting for some daj^s after. Temperatures aver- 

 aged only slightly above normal for the first ten days (.2° to .3° above), 

 and below normal for the succeeding thirty days (.1° to .5° below). 

 The raw surface resulting from breaking of abscess gradually healed, 

 the edges of the lesion showing verrugas from November 2 to 13, these 

 being constantly destroyed by the never-ending action of the animal's 

 tongue. November 20 a small verruga had formed on forehead, and 

 a larger one on outside of tip of right ear-lobe, both of which graduallj^ 

 increased to November 26 and 27 when they sloughed. November 22 

 showed eruptive scabbing on left ear-lobe and left jowl, these continu- 



