406 



ANTAGONISTIC EFFECTS OF BILE SALTS 



At all the concentrations employed there was an immediate increase 

 in resistance^ followed by a fall, as illustrated in Fig. 1. Under the 

 conditions of the experiment (temperature 19° ± 2°C.) the rise lasted 

 about an hour. The effect is comparable with that of anesthetics* 

 (ether, chloroform, and alcohol) as described by the writer. An in- 



100%- 



50%- 



100 

 MINUTES 



Fig. 1 . Curve showing decrease of permeability (rise in net electrical resistance 

 expressed as per cent of the control in sea water) of Laminaria, produced by add- 

 ing 1 gm. of sodium taurocholate to 1,000 cc. of sea water (solid line). Control 

 in sea water, dotted line. The resistance is expressed as per cent of the normal 

 resistance in sea water, which is taken as 100 per cent. Average of two experi- 

 ments; probable error less than 2.3 per cent. 



crease in resistance was also observed with Ulva rigida and with Rho- 

 dymenia palmata. 



In the experiments on antagonism the tissue was placed in a solu- 

 tion of NaCl 0.52 m to which various amounts of sodium taurocholate 



^ For convenience all the resistances are expressed as per cent of the normal 

 resistance in sea water which is taken as 100 per cent. 

 « Cf. Osterhout, W. J. V., BoL Gaz., 1916, Ixi, 148. 



