408 ANTAGONISTIC EFFECTS OF BILE SALTS 



merely the algebraic mean between a rise in resistance produced by 

 the bile salt and a fall produced by NaCl. A consideration of the 

 lowest curve shows that at 180 minutes the tissue is dead in NaCl 

 0.52 M as well as in 1,000 cc. of NaCl 0.52 m + 10 gm. of sodium tauro- 

 cholate, but in the mixture containing only 0.5 gm. of taurocholate 

 it is not yet half dead, its resistance being much higher than in the 

 other mixtures.'' 



The result serves as a striking confirmation of the idea that antago- 

 nistic relations can be predicted, to a considerable extent at least, by 

 ascertaining the effect upon permeability of each substance taken 

 by itself, inasmuch as substances which decrease permeability antag- 

 onize those which increase it. 



SUMMARY. 



Sodium taurocholate is able to produce a decrease in permeability 

 and to antagonize NaCl. This confirms the hypothesis that an- 

 tagonistic relations can be predicted from studies on the permeability 

 of pure substances. 



' At the end of 180 minutes the resistance of the control in sea water was 100 

 per cent. 



