LIBRARY 

 JOURNAL BOTANICAJL 



OF THE "JARDJEN 



ROYAL MICROSCOPICAL SOCIETY. 



JUNE, 1879. 



TRANSACTIONS OF THE SOCIETY. 



XIX, — On the Development and Betrogression of the Fat-cell. 

 By George Hoggan, M.B., and Fkances Elizabeth Hoggan, M.D. 



(Bead 12th March, 1870.) 



Plates XIII. and XIV. 



Part I. — Development of the Fat cell. 



If in the animal body there be one element whose simple struc- 

 ture and generally accessible position would lead us to expect that 

 its life-history could easily be traced, and that consequently a 

 general unanimity of opinion regarding it must necessarily exist 



DESCRIPTION OF THE PLxVTES. 

 Plate XIII. — Development of Fat-cells. 



Fig. 1. — First deposition of fat in wandering cells retracted into a globular 

 form, from broad ligament of pregnant mouse, a. First appearance of fat in a 

 cell as two minute oil-globules, h, c, d, e, f. Cells in which gradual increase of 

 contained fat can be traced towards the capillary, g. Cells similar to a in which 

 no fat has as yet been deposited. All the above cells lie beneath the endothelium 

 and in the matrix of the membrane, h. A wandering cell with constricted 

 nucleus lying in one of the h.des iu the membrane, and therefore on the free 

 surface; it is evidently only a younger form of '/ and h. i,j. Still younger spe- 

 cimens of wandering cells lying on the free surface of the membrane ; i has two 

 nuclti. k. Nuch i of the endothelium covering both surfaces of the membrane. 



Fig. 2. — Eelation of fat - tracts to wandering cells, from mesentery of rat. 

 d, e. Members of a shoal of wandering cells lying on free surface of endothelium. 

 a. A member of (he same kind of cells, but lying beneath the surface of the 

 endothelium, h, c. Cells similar to the above, but further advanced, lying also 

 underneath the endothelium and becoming fat-cells ; b has already" two fot- 

 globules within it, and has atttched itself to the group of fat-cells of which / is 

 a fully developed specimen. Only the cell-markings of the upper surfi ce endo- 

 thelium are drawn, except at a, where the dotted line marks the low" surface 

 cell-markings. 



Fig. 3. — First depositicm of fat in wandering cells fixed in their branhed con- 

 dition, from the broad ligament of a pregnant mouse. All these cells lie in the 

 matrix of the membrane. Nuclei of endothelium not inserted. 



Fig. 4.— Fat-cells developing centrally as regards the blood-vessel, from the 

 broad ligament of a pregnant rat. g, g. Fat beginning to be deposited in cells 

 close to the blood-vessel, a, a. Cells fully distended with fat, lying farther away 

 from bldoil-vessel ; in these cells the fat has been slowly and steadily accumu- 

 lating. 6, 6. Cells containing many fat-globules, the result of rapid deposition. 



Fig. 5. — From the mesentery of a rat found starving, to which plenty of rich 



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