150 THEORY OF INJURY AND RECOVERY 



On replacing the tissue in sea water, therefore, we start with M = 

 70.69 and A = 2,027.96, but this value of A is at once augmented 

 by the conversion of S into A . In order to find the amount of this 

 augmentation we must know the value of S. 



During exposure to NaCl the reaction R —> S -^ T occurs. The 

 value of 5 may be easily calculated by employing formula (1) and 

 substituting the appropriate constants. We thus obtain 



in which So denotes the value of 5 at the start of the reaction. The 

 value of R in sea water is taken as 1,041.77 and that of 5 as 2.7. In 

 the solution of NaCl the values of Kji (the velocity constant of the 

 reaction R ^ S) and Ks (the velocity constant of the reaction S ^ T) 

 are taken as 0.04998 and 0.02856 respectively (see Table I). Hence 

 the value^^ of S at the end of 15.9 minutes is 447.26. When the tissue 

 is replaced in sea water S is rapidly converted into A so that the total 

 value of the latter becomes 447.26 + 2,027.96 = 2,475.22. 



On replacing the tissue in sea water A — 2,475.22 and M = 70.69. 

 The resistance after any given time T in sea water is obtained by modi- 

 fying formula (1) which becomes 



Resistance = 2,475.22 ( ^^ ^^ j ^"^'^^ - e'^^^j + 70.69^-^'^^) (4) 



The velocity constants /v^ and Km have the normal values in sea 

 water, 0.0036 and 0.1080 respectively. Hence the resistance at the 

 end of 10.6 minutes is 87.44. 



We must likewise remember that on replacing the tissue in sea 

 water the reactions O ^ S ^> A recommence and produce a certain 

 amount of A ; this breaks down to form Af , which in turn decomposes. 

 The resulting amount of M may be easily calculated. It will be re- 

 called that in sea water all processes are so adjusted that the amount 

 of M remains constant; it is evident that if the reactions O -^ S -^ A 

 were suddenly to stop, allowing A —^ M —^ B to continue, the amount 

 of M would diminish. At the start the total resistance is 100. If O 



^^ In general the greater the rise in recovery the greater the value of 5, while 

 the greater the fall the less the value of 5. 



