EDUARD UHLENHUTH 365 



tion to the fact that in acromegaly the tendency to abnormal growth 

 is confined to the prominent parts of the body, in which the tempera- 

 ture is lower than in the main body. 



SUMMARY. 



1. Metamorphosed salamanders of the species Amhystoma opacum 

 and Amhystoma tigrinum were fed on a pure diet of the anterior lobe of 

 the hypophysis of cattle; the controls were fed on an abundant diet of 

 earthworms. 



2. The rate of growth of the animals fed on the anterior lobe of the 

 hypophysis was greatly increased over the rate of growth of normal 

 animals. 



3. Growth of the animals fed on anterior lobe did not cease after 

 they had reached the normal "maximum" size of the species, and 

 experimental giants were produced. 



4. The largest animal of the species Amhystoma opacum fed on 

 anterior lobe of the hypophysis was 19 mm. larger than the largest 

 normal animal of this species known to the writer; the largest animal 

 of the species Amhystoma tigrinum fed on anterior lobe is at present 

 about 28 mm. larger than the largest normal animal of the eastern 

 race of this species known to the writer. 



