12 Journal of the Mitchell Society [May 



stances effect a diuretic action. Salt solution, 0.9 per cent, 

 shows a more constant diuretic effect, and the increase in the 

 flow of urine from the salt is more pronounced than it is from 

 the other substances. 



THE KENAL PATHOLOGY 



Five of the animals used in this investgiation were killed 

 either prior to the anesthetic or during its administration. 

 Four of these animals had an early uranium nephritis, were 

 markedly polyuric and had a glycosuria. The fifth animal had 

 a late uranium nephritis, was glycosuria but was not polyuric. 

 The out^Dut of urine was reduced below the normal. 



In the four early nephritides the vascular pathology of the 

 kidney was much more pronounced than was the epithelial 

 pathology, while in the fifth animal with a late uranium nephri- 

 tis in which the output of urine had been reduced below the 

 normal, the ej)ithelial pathology predominated. The vascular 

 pathology in the early nephritides consisted primarily of an 

 acute engorgement of the glomerular capillaries. The hyi)er- 

 aemic capillary tufts usually filled the space enclosed by Bow- 

 man's membrane and frequently this structure gave the appear- 

 ance of being distended by the enclosed capillaries. The endo- 

 thelial nuclei of the capillaries and of the capsular membrane 

 showed no degeneration but were unusually prominent. Within 

 the capilliaries the vacuoles first described by Christian (6) 

 were observed in two of the kidneys. 



The intertubular vessels showed the same engorgement with 

 an occasional intertubular exudate containing a few erythro- 

 cytes. 



With this pronounced vascular reaction on the part of the 

 kidney the epithelial pathology was remarkably slight. The 

 epithelium had not degenerated, it stained well and showed no 

 encroachment upon the lumen of the tubules. (Figs. I and II.) 



A comparison of the epithelial changes in these animals, with 

 the epithelial changes in those animals having a complete 

 anuria is as striking as is the difference in the output of urine 

 by the two groups of animals before and after the administra- 

 tion of an anesthetic. 



