1912~\ A Study of the Action of Diuketics 13 



Four of the anuric animals were in an early stage of uranium 

 nephritis, the stage which has just been described as existing in 

 the animals killed before the administration of an anesthetic. 

 In these animals with an early uranium nephritis which were 

 polyuric and glycosuric, and which following the anesthetic 

 became anuric, the vascular pathology was histologically sim- 

 ilar to the vascular pathology noted in those animals that had 

 not been subjected to the effect of an anesthetic. The epithelial 

 pathology in these two groups of animals shows, however, a well 

 marked difference. The epithelium in the anuric animals is 

 very greatly swollen and is usually vacuolated. As a result of 

 the swelling the lumen of the tubules has either been very 

 greatly encroached upon or the lumen has become obliterated 

 by an apposition of the opposing faces of the tubular epithelium. 

 The epithelial changes are most pronounced in the convoluted 

 tubules. (Figs. Ill and IV.) 



In the animals grouped as practically anuric, the renal path- 

 ology is so nearly similar to the pathology of the kidney in the 

 anuric group that the two allow no histological differentiation. 



In the animals grouped as diuretic, the vascular pathology is 

 similar histologically to the vascular pathology which has been 

 described for those animals in the anuric group and also for 

 those animals which were killed prior to the use of the anes- 

 thetic. The epithelial pathology, however, differes very much 

 from the epithelial pathology of the anuric group but resembles 

 in its appearance the epithelial reaction seen in those diuretic 

 animals obtained before the use of an anesthetic. (Figs. V 

 and VI.) 



SUMMAEY 



1. Early in a uranium nephritis, usually within the first 

 twenty-four hours, the animals develop a glycosuria and be- 

 come markedly polyuric. 



2. Following an anesthetic, morphine-ether, or Grehant's, 

 these animals either become completely anuric or the output of 

 urine is greatly reduced. 



3. Such animals under the effect of caffeine, theobromine, 

 digitalin and 0.9 per cent salt solution, show a normal response 



