1912^ A Study of the Action of Diuretics 15 



BIBLIOGRAPHY 



(1) MacNider: Journal of Medical Research, vol. xxvi, no. 1 (to be 

 published). 



(2) Schlayer and Hedinger: Deutsch. Arch. f. klin. med., 1907, xc, 1. 



(3) Pearce, Hill and Eisenbrey: Jour. Exp. Med., vol. xii, no. 2, 1910. 



(4) Heineke and Myerstein: Deutsch. Arch. f. klin. med., 1907, vol. 

 xc, 101. 



(5) Dickson: Arch. Int. Med., 1909, vol. iii, p. 375. 



(6) Christian: Boston Med. and Surg. Jour., 1908, clix, 8. 



(7) Schirokauer: Ztsch. f. klin. Med., 1908, Ixvi, 182. 



Figs. I and II 



The figures represent the kidneys of a nephritic, glycosuric and 

 polyuric animal before the use of an anesthetic. The glomerular ves- 

 sels fill and distend the surrounding capsule and show the presence of 

 vacuoles in the capillary walls. The tubular epithelium shows oc- 

 casion vacuolation, is but slightly swollen and has not encroached 

 upon or occluded the lumen of the tubules. The tubules contain gran- 

 ular detritus. B. and L. obj. 3, oc. 1. 



Figs. Ill and IV 



The figures represent the kidneys of two animals which were ex- 

 cessively polyuric before the administration of an anesthetic. Follow- 

 ing the anesthetic the animals became anuric. The anuria remained 

 uninfluenced by the diuretics. The vascular pathology is histological- 

 ly similar to the pathology described in the polyuric animals illus- 

 trated by Figs. I and II. The epithelial pathology, however, is strik- 

 ingly different. The epithelium shows an acute swelling resulting in 

 a nearly complete occlusion of the lumen of the tubules. The acute 

 nature of the swelling of the epithelium is well shown in Fig. III. The 

 anuria was uninfluenced by the diuretics. B. and L. obj. 3, oc. 1. 



Figs. V and VI 



The figures represent the kidneys of two animals which were re- 

 sponsive to the diuretics. The vascular pathology is similar to that 

 described in the anuric animals. The epithelium shows but slight 

 swelling and no material encroachment upon the lumen of the tubules. 

 B. and L. obj. 3, oc. 1. 



Chapel Hill, N. a 



