1912'] A Study of the Action of Diuretics 11 



In three of the experiments of this series 0.9 per cent salt 

 was used. With the salt solution the greatest degree of diuresis 

 was produced and this diuretic effect from the salt was more 

 constant than that from the other diuretics in this type of 

 nephritis. 



In experiment 19, the flow of urine in the half hour period 

 prior to the use of salt solution was 0.9 cc. Following the salt 

 with a rise in arterial pressure of 14 mm. and in oncometer 

 pressure of 49 mm. the urine increased 1.7 cc. 



In experiment 17 with a flow of urine of 1.6 cc. — prior to 

 the use of salt solution, following its use the urine increased to 

 4.6 cc. The oncometer pressure rose 18 mm. and the general 

 pressure 6 mm. 



The following deductions concerning the diuretic value of the 

 different substances employed in these groups of experiments 

 are as follows: 



1. In the anuric group, caffeine, theobromine, digitalin and 

 0.9 per cent salt solution have no effect in reestablishing the 

 flow of urine. Their failure does not depend upon their inabil- 

 ity to raise and maintain a sufficiently high general blood pres- 

 sure to produce diuresis. 



2. The inactivity of these substances is not due to their in- 

 ability to influence the local renal circulation, for the physio- 

 logical vascular response of the renal vessels as indicated by 

 the oncometer readings is normal or hyperactive. 



3. In the group of experiments classified as practically 

 anuric the same deductions concerning the inefficiency of the 

 diuretics are allowable. 



4. In addition to these deductions relative to the effect of 

 the diuretics, this group also shows that the quantity of urine 

 may not only not be increased by the diuretics, but that the out- 

 put of urine may progressively decrease, even though the general 

 blood pressure readings and oncometer readings show the usual 

 response. 



5. In the diuretic group in which the animals show the same 

 physiological response to the diuretics as was shown by the 

 animals in the anuric and practically anuric groups — the sub- 



