10 Journal of the Mitchell Society [^May 



in oncometer pressure from theobromine. During the last half 

 hour of the experiment, under the effect of 0.9 per cent salt 

 the arterial pressure rose 17 mm. and the oncometer pressure 

 20 mm. The urine filled the ureter canula and a few drops 

 were discharged into the receiving flask. 



Experiment 11 followed the same general course. Prior to 

 the anesthetic the animal was highly poljuric. Following the 

 anesthetic the output of urine for the first half hour period was 

 2 cc. The urine flow then decreased, although the animal 

 showed the usual physiological response to caffeine and theo- 

 bromine. During the final half hour period of the experiment 

 the flow of urine had been reduced to two drops. The experi- 

 ment demonstrates a continuance of those changes, whatever 

 they may be, which lead to an anuria, and which commence with 

 the administration of the anesthetic, and in this instance have 

 progressed, uninfluenced by the employment of diuretics. 



Diuretic group 



In the animals classified as diuretic, the term is used rela- 

 tively. With few exceptions these experiments were terminated 

 artificially during a period of diuresis. Such a termination 

 does not exclude the possibility of the animal later becoming 

 anuric as was illustrated in the previously described experiment. 

 The following experiments are representative of this group: 

 Experiment 16. The animal had a pronounced nephritis, 

 was polyuric and had developed a glycosuria. Following 

 Grehant's anesthetic the animal became anuric for fotry-five 

 minutes. Following the use of caffeine, with a rise of arterial 

 pressure of 5 mm. of mercury and of oncometer pressure of 8 

 mm. the urine fiow was reestablished and during the half hour 

 period following the use of caffeine the flow of urine was 1.5 cc. 

 Under theobromine without a rise in arterial pressure but with 

 a rise in oncometer pressure of 4 mm., the flow of urine in- 

 creased to 3 cc. in a half hour period. With digitalin which 

 produced a rise in arterial pressure of 10 mm. and in oncometer 

 pressure of 8 mm. the urine flow increased to 3.3 cc. in a half 

 hour interval. 



