1912'\ A Study of the Action of Diuretics 9 



THE effect of DIURETICS IN URANIUM NEPHRITIS 



To facilitate the study of the effect of the different diuretics 

 the experiments have been classified into groups, e. g., the 

 Anuric, Practically Anuric and Diuretic Groups. 



Anuric group 



Six experiments are included in this group. In all six of the 

 animals caffeine, theobromine, and digitalin were employed as 

 diuretics and in four of the animals 0.9 per cent salt was also 

 used. ISTone of these agents had any effect in reestablishing a 

 flow of urine. This failure cannot be attributed to either a 

 failure on the part of the diuretics to increase and maintain an 

 adequately high general blood pressure for urine secretion, or to 

 a failure in the vascular response of the kidney. The following 

 experiment will serve well to illustrate these points : 



Experiment 23. The animal's general blood pressure at the 

 commencement of the experiment was 104 mm. of mercury and 

 at the termination 107 mm. Caft'eine produced a rise in arterial 

 pressure of 4 mm. of mercury and a rise in the oncometer of 27 

 mm. (water manometer). Theobromine produced a rise of 7 

 mm. in general pressure, and a rise in oncometer pressure of 

 59 mm., digitalin a rise of 18 mm. in arterial pressure and 20 

 mm. in oncometer pressure, while 0.9 per cent salt caused no 

 rise in general blood pressure, but a rise of 15 mm. in oncome- 

 ter pressure. The animal remained anuric throughout the ex- 

 periment. 



Practically Anuric group 



Falling in this group are experiments 6 and 11. They rep- 

 resent animals which are not absolutely anuric but which show 

 a gradual decline in the flow of urine which is but slightly influ- 

 enced by the diuretics. 



The first animal of this series, experiment 6, j^rior to the 

 anesthetic had an output of urine of 810 cc. Following the an- 

 esthetic an anuria developed for two hours, although during 

 this time a rise of blood pressure of 14 mm. of mercury and of 

 oncometer pressure of 12 mm. of water was obtained from 

 caffeine and a rise of 10 mm. in general pressure and of 12 mm. 



