8 Journal of the Mitchell Society ^May 



viously mentioned. Within thirty-four minutes to an hour and 

 a half after the commencement of the anesthetic, the output of 

 urine from these excessively diuretic animals was either very 

 greatly reduced, reduced to a condition bordering on an anuria, 

 or an anuria had developed, which in six of the animals per- 

 sisted throughout the experiment, uninfluenced by the diuretics 

 which were employed. 



This pronounced reduction in the output of urine after the 

 anesthetic is equally as striking as is the increase in the output 

 of urine, after the animals have developed a glycosuria. 



Experiment 20 is used to illustrate these observations. The 

 animal was receiving 500 cc. of water daily. The average 

 outjDut of urine for the three days prior to the uranium was 

 464 cc. The animal was given subcutaneously one injection of 

 uranium of 10 mgs. The animal rapidly developed a nephritis 

 and a glycosuria, and the urine increased to 1018 cc. At the 

 time of the experiment 294 cc. of this urine was found in the 

 bladder, which shows quite clearly that the animal was diuretic 

 until the time of anesthesia. The exj)eriment lasted four hours 

 and during this time the animal was in a perfectly satisfactory 

 physiological condition. The general blood pressure varied 

 between 93 and 108 mm. of mercury and the renal vessels were 

 physiologically responsive to caffeine, theobromine and 0.9 per 

 cent salt. Not a drop of urine was voided. 



This experiment, associated as it is with others which give 

 identically the same results, shows a definite relation between 

 the polyuria and the development of glycosuria. Secondly, it 

 shows an equally intimate connection between the use of an 

 anesthetic and the development of an anuria. The polyuria in 

 uranium nephritis and the influence of the anesthetic in reduc- 

 ing the output of urine has been observed by both Schlayer (2) 

 and Pearce (3). Pearce attributes the anuria to a "decreased 

 glomerular permeability" and makes a similar suggestion to 

 interpret the results obtained by Schlayer. So far as I have 

 been able to learn these authors make no note of the association 

 of the polyuria with the onset of the glycosuria. 



