4 Journal of the Mitchell Society [May 



an exaggerated contraction and dilatation of the vessels and 

 also an increased diuresis. Arsenic and cantharidin acted as 

 vascular poisons and produced but little injury to the tubules. 

 Both of these poisons tended to cause an anuria which was char- 

 acterized by minimal contraction and dilatation of the renal 

 vessels and little or no flow of urine. Finally, in this investiga- 

 tion two types of late tubular nephritis are described: one 

 anuric and accompanied by gastro-intestinal symptoms; and 

 the other polyuric until the time of anesthesia. 



In addition to these two investigations which are principally 

 concerned with the physiological response of the kidney, patho- 

 logical studies of the kidney in a uranium nephritis have been 

 made by several investigators. 



Heineke and Myerstein (4) were able to demonstrate a 

 marked vascular disturbance in the kidney from uranium in 

 addition to a pronounced action on the renal epithelium ; while 

 Dickson (5) in an extensive series of experiments in which the 

 guinea pig was the animal employed came to the same conclu- 

 sions. 



Christian (6) in his work on uranium nephritis in which the 

 vascular pathology was studied, described as developing in the 

 capillaries of the glomerulus, oval or irregular homogeneous 

 droplets 0.5 to 4 microns in diameter. Similar structures have 

 been observed in several of the experiments in the series of 

 animals which will be presented in this study. 



The work of Schirokauer (7) on the uranium nephritis of 

 rabbits is of special interest on account of the associated 

 anasarca. 



DISCUSSION of the TECHNIQUE EMPLOYED IN THE EXPERIMENTS 



In conducting the experiments the dog was the animal con- 

 stantly employed. A total of twenty-three animals were used. 

 The animals were free from disease and their general nutrition 

 was apparently normal. 



For three days prior to the experiments the animals were 

 kept in metabolism cages, fed on beef and hard bread and given 

 once a day by stomach tube a known and constant quantity of 

 water. The quantity of water varied with the size of the ani- 



