JOURNAL 



OF THE 



Elisha Mitchell Scientific Society 



VOLUME XXVIII MAY, 1912 No. 1 



A STUDY OF THE ACTION OF VAEIOUS DIURETICS 

 IN UEANIUM NEPHRITIS 1 



By Wm. deB. MacNidee. 



Introduction 1 



Review of Literature 3 



Discussion of the technique employed in the experiments 4 



Course of the experiments 7 



The effect of diuretics in uranium nephritis 9 



The renal pathology 12 



Summary 13 



Bibliography 15 



In a recent anatomical study ( 1 ) of the nephritis produced in 

 the dog by the use of various nephrotoxic substances it has been 

 shown that these substances vary to some extent in the degree 

 of their selective affinity for the different kidney tissues. Arse- 

 nic, for example, has a striking affinity for the blood vessel 

 tissue of the kidney; while potassium dichioraate causes an 

 involvement of the epithelial element of the kidney much earlier 

 than does any of the usually employed nephrotoxic substances. 



Uranium nitrate, a substance which has frequently been 

 employed to produce experimentally a nephritis, in its avidity 

 for the different tissues of the kidney, is not so selective in its 

 action as are the poisons just mentioned. 



If uranium be given in large doses subcutaneously, or if 

 smaller quantities be used and the nephritis be allowed to per- 

 sist for some days, the nephritis which it induces with such a 

 technique is more tubular than vascular. If, on the other hand, 

 small quantities are employed, 5 to 10 mgs. per animal, and if 

 the nephritis be terminated early, the reaction on the part of the 



^ Presented in abstract before the Society for Pharmacology and Experimental 

 C*»J Therapeutics, Baltimore, December 27, 1911. Reprinted from The Journal of 



^~' Pharmacology and Experimental Therapeutics, Vol. Ill, No. 4, March, 1912. 

 Ct5 



