100 



Journal of the Mitchell Society [December 



imate amount of hematin liberated into the human host with 

 the segmentation of a given generation of parasites. Basing 

 our calculations on the presence of 8.5 grams of hemoglobin 

 per kilo of body weight, and 4.47 per cent, of hematin in hem- 

 oglobin,^ we find that in a 1 per cent, infection of the red blood 

 corpuscles approximately 3.7 milligrams of hematin per kilo 

 of body weight would be liberated. In my experiments the 

 dosage has varied from 1.3 milligrams to 28 milligrams per 

 kilo of body weight, given in single or in divided doses, corres- 

 ponding roughly to an infection of 0.3 to 7.5 per cent, of the 

 red blood corpuscles. 



Normal Temperature of the Babbit. — ^In undertaking an 

 investigation which must necessarily deal so largely with varia- 

 tions in the temperature of the experimental animal, it is im- 



Text-fig. i. Normal temperature of four rabbits during the period of 



the experiments. 



perative that the basis of comparison between normal and 

 abnormal fluctuations of temperature be as free from objection 

 as possible. Unfortunately, the temperature of different rabbits 



= 01of Hammarsten, A Text Book of Physiological Chemistry, translated by 

 Mandel, New York, 1901, p. 139. These figures are probably high. 



