1912] Malarial Pigment in Malarial Paroxysm 



103 



to one hour, followed by a secondary rise of variable extent and 

 duration or a very gradual decline requiring several hours to 

 reach normal again. Two such temperature curves are sho\vn 

 in text-figure 2. 



These curves are subject to innumerable variations depending 

 upon the dose, the stage of the experiment, and upon the indi- 

 vidual peculiarities of animals. Some of the more important 

 variations are an accentuation and prolongation of the secon- 

 dary rise, usually shown with initial and large doses, or a 

 defervesence that is almost as sharp as the rise in temperature. 

 A third variation, which includes the three exceptions previ- 

 ously noted, is met with in instances of marked Intoxication 

 and is characterized by an initial drop in temperature with a 

 subsequent rise. All three of these modifications are illus- 

 trated in text-figure 3. 



Text-Fig. 3. Variations in the temperature curve following large doses 

 of hematin or repeated injections of hematin. 



