A STUDY OF THE ACTION OF VARIOUS DIUEETICS 

 IN URANIUM NEPHRITIS, WITH SPECIAL REF- 

 ERENCE TO THE PART PLAYED BY THE 

 ANESTHETIC IN DETERMINING THE 

 EFFICIENCY OF THE DIURETIC^ 



Wm. deB. MacNider 



Prom the Laboratory of Pharmacology of the University 

 of North Carolina^ 



Received for publication, May 8, 1913 



Synopsis 491 



Introduction 492 



Review of previous experiments 492 



Discussion of the technique employed in the experiments 494 



The eflfect of uranium nitrate on the output and composition of the 



urine in young and full-grown animals 496 



The effect of Grehant's anesthetic on the output and composition of 



the urine in young and in adult dogs, nephritic from uranium. . . . 499 

 The effect of morphine-ether on the output and compostion of the 



urine in young and in adult dogs, nephritic from uranium 502 



The efficiency of various diuretics in uranium nephritis in animals 



anesthetized with Grehant's anesthetic and with morphine-ether. . 504 

 The difference in the renal pathology of animals or diuretic following 



Grehant's anesthetic 506 



The difference in the renal pathology of animals anuric or diuretic 



following morphine-ether 509 



General discussion of the experimental data 509 



Conclusion 513 



Bibliography • 515 



In a previous number of this journal (1), a report was made 

 on the action of various diuretic substances in animals rendered 

 nephritic by uranium nitrate. The animals employed in this 

 series of experiments could be classified, on a basis of their re- 



^ Presented in abstract before the Society for Pharmacology and Experimental 

 Therapeutics, Cleveland, December 30, 1912. Aided by a grant from the fund 

 for Scientific Research of the American Medical Association. 



2 Reprinted from The .Tournal of Pharmacology and Experimental Therapeutics, 

 Vol. IV, No. 6, July, 1913. 



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