34 JOUENAL OF THE MlTCHELL SoCIETY [June 



sponse to diuretics, into three groups: an anuric, a practically 

 anuric, and a diuretic group. 



In the present invesitgation, which is a direct continuation of 

 the previously mentioned experiments, the same general group- 

 ing of the animals can be established. It has been experiment- 

 ally demonstrated, however, that the practically anuric group 

 is an unnnecessary refinement in the classification, for the con- 

 dition of partial anuria should be interpreted as a forerunner of 

 the anuric state which sooner or later develops, provided the ex- 

 periment be continued. Therefore, in the present report the 

 observations will be confined to two groups of nephritic animals : 

 a diuretic group and an anuric group. 



The present investigation shows, also, that whether or not the 

 animals are diuretic or anuric following the anesthetic depends 

 very largely upon the anesthetic employed and upon the age of 

 the animals. As a result of this observation, in addition to a 

 continuation of the study of the response of the pathological 

 kidney to diuretics, it becomes especially necessary to consider 

 the response of the pathological kidney to different anesthetics. 



REVIEW OE PEEVIOUS EXPERIMENTS 



In the experimental work previously published it was shown 

 that when dogs were given uranium nitrate subcutaneously in 

 the dose of from 5 to 10 mgs. the animals developed an albu- 

 minuria, which was followed within twelve to forty-eight hours 

 by a glycosuria. The output of sugar in the twenty-four hour 

 specimen of urine varied within wide limits: 0.25 to 3.22 per 

 cent. !No determination of acetone or acetone bodies was made. 



It was also shown that either just prior to the development of 

 the alubuminuria, or associated with its development the output 

 of urine increased, and that with the development of the gly- 

 cosuria the animal became highly polyuric. For instance, in 

 experiment 8, of the previously mentioned series the animal was 

 receiving 500 cc. of water daily; the average output of urine 

 prior to the uranium was 513 cc. ; while following the uranium 

 and with the development of a nephritis and a glycosuria the 

 urine increased to 1310 cc. 



